Pediculosis is an ectoparasitic disease caused by the infestation of the head lice Pediculus capitis. It has a high prevalence rate in developing countries because it is mistakenly considered as a naturally occurring disease among schoolchildren with no public health programs geared towards eradicating it. This study determined the prevalence of pediculosis among schoolchildren of Calagtangan Village, Miag-ao, Iloilo, and the percent reduction in the prevalence after treatment using a dry-on, suffocation-based pediculocide (Cetaphil). A mass screening of the schoolchildren of the village was performed by house-to-house survey. Results showed an overall prevalence of pediculosis of 85%, and significantly twice as many females (66%) afflicted compared to males (33%). Results also showed a marked decrease in the prevalence of pediculosis after the first week (44%) and last week (0.03%) of Cetaphil treatment. The overall cure rate was 97.2%. No topical or systemic adverse reactions to the treatment modality were reported by the parents and/or children. This shows that the dry-on, suffocation based-pediculocide is effective in reducing the high prevalence rate of pediculosis in the study area.