Philippine Science Letters
vol. 4 | no. 2 | 2011
published online July 14, 2011


Novel Glycerol-Crosslinked Poly(acrylic acid) Hydrogel for Encapsulation and Release of Benzocaine

by Angela Lisandra S. Lee, Gayzen A. Ordoņez, Soma Chakraborty*

Department of Chemistry, School of Science and Engineering, Ateneo de Manila University, Loyola Heights, Quezon City 1108 Philippines



Drug delivery by a controlled-release mechanism offers several advantages over traditional delivery systems such as improved therapeutic activity, reduced number of drug administrations, as well as minimizing the risk of over-dose or under-dose. In this study, attempt has been made to develop a novel controlled release device from glycerol crosslinked poly(acrylic acid) hydrogels. Glycerol crosslinked poly(acrylic acid) was fabricated by polymerizing acrylic acid and crosslinking the polymer with glycerol in the same reaction pot in the presence of benzoyl peroxide and Novozym 435. The fabricated hydrogel swelled more than 100% in neutral, acidic and basic buffer solutions. Swelling was pH and temperature dependent. The hydrogel encapsulated the drug benzocaine; the amount encapsulated was dependent on time, temperature and initial benzocaine concentration. The hydrogel also released the drug at a controlled rate.

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Submitted: January 20, 2011
Revised: June 23, 2011
Accepted: July 1, 2011
Published: July 14, 2011
Editor-in-charge: Gisela P. Padilla-Concepcion
Aaron Joseph Villaraza
Portia G. Sabido
Nemesio E. Montaņo