Probiotic bacteria isolated from locally available commercial dairy products, namely, Nestle Chamyto Probiotic Drink, Yakult Probiotic Drink, Nestle Cerelac Infant Cereal, and Nido 3+ Powdered Milk were established to have antimicrobial activities using the agar spot assay. Tester strains used were extended-spectrum ▀-lactamase (ESBL)-producing strains of Enterobacter aerogenes, Klebsiella pneumoniae, Proteus mirabilis, and Escherichia coli, metallo-▀-lactamase (MBL)-producing strain of Pseudomonas aeruginosa, and three strains of methicillin resistant Staphylococcus aureus (MRSA). The probiotics inhibited the growth of all the tested multiple drug resistant strains. Further tests showed that the isolate from Chamyto displayed bactericidal activities on all the test strains. Yakult and Nestle Cerelac probiotics were bactericidal for all strains except for ESBL-producing E. coli. Nido 3+ probiotic isolates were bactericidal for all strains except for ESBL -producing K. pneumoniae. The probiotic isolates were identified phenotypically and through 16S rDNA analysis to be Lactobacillus casei or Lactobacillus paracasei. The in vitro bactericidal activities of the isolated probiotics show great potential for further research in treatment and prophylaxis of infections from multiple drug resistant bacteria.