Philippine Science Letters
vol. 6 | no. 1 | 2013
published online March 15, 2013


A new macrolide isolated from the endophytic fungus Colletotrichum sp.

by Melfei E. Bungihan1,2 , Mario A. Tan*,1, Hiromitsu Takayama3, Thomas Edison E. dela Cruz1, and Maribel G. Nonato1

1 The Graduate School and Research Center for the Natural and Applied Sciences,
   University of Santo Tomas, España, Manila 1015 Philippines
2 Saint Mary’s University, Bayombong, Nueva Vizcaya 3700 Philippines
3 Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana,
   Chuo-ku, Chiba 260-8675 Japan



A new macrolide, colletotriolide (1), was isolated from the endophytic fungus Colletotrichum sp. isolated from Pandanus amaryllifolius by a series of chromatographic techniques. Its structure was determined based on HR-MS, 1D and 2D NMR. In addition, tyrosol C (2) isolated from the fungus Colletotrichum gloeosporioides, and dothiorelone C (3) and cytosporone (4), both isolated from the fungus Chaetomium globosum, were also identified in this study. All three fungi were isolated from the leaves of Pandanus amaryllifolius. Biological evaluation showed that 1 has a low activity against Escherichia coli, while 4 is moderately active. Compounds 1, 3 and 4 were inactive against the A549, HT29 and HCT116 cell lines.

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Submitted: November 6, 2012
Revised: February 19, 2013
Accepted: February 22, 2013
Published: March 15, 2013
Editor-in-charge: Gisela P. Padilla - Concepcion