Philippine Science Letters
vol. 2 | no. 1 | 2009
published online: December 10, 2009
Received: October 28, 2009
Revised: December 1, 2009
Accepted: December 1, 2009
Editor-in-charge: Gisela P. Padilla - Concepcion


Conantokins: from “sleeper” activity to drug development
by Elsie C. Jimenez


The conantokins belong to a distinctive family of Conus peptides which are known to have sleepinducing activity in young mice, and are found to be inhibitors of N-methyl-D-aspartate (NMDA) receptors. This paper presents an overview of the various conantokins characterized so far, with focus on the biochemistry, solution structures in the absence or presence of divalent cations, function as selective NMDA receptor antagonists, and potential as therapeutic agents for some neurological conditions associated with NMDA receptor dysfunction.