Philippine Science Letters
vol. 5 | no. 2 | 2012
published online July 20, 2012


Design of possibly useful vaccines against human immunodeficiency virus 1

by Eduardo A. Padlan

The Marine Science Institute, College of Science
University of the Philippines Diliman
Quezon City 1101, Philippines



Possibly useful vaccines against human immunodeficiency virus 1 are designed based on the interaction of the A/E 93TH057 gp120 core, variant V65C/S115C, with antibody NIH45-46, a broadly neutralizing antibody. The antigenicity of this gp120 core is modified by replacing all the solvent-accessible residues with amino acids that are less reactive, except those residues which constitute the epitope of NIH45-46. The antibodies elicited by these vaccines are expected to be focused on this epitope and should also be broadly neutralizing.

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Submitted: February 6, 2012
Revised: June 1, 2012
Accepted: June 3, 2012
Published: July 20, 2012
Editor-in-charge: Leodevico L. Ilag
Leodevico L. Ilag
Vijay S. Reddy